Gail Simone is well known among the comic book community for coining the term “Women in Refrigerators” and writing the original list. She began a weekly column, entitled "You'll All Be Sorry!", which she updated regularly for two years. After scripting contributing several stories for The Simpsons, she entered superhero comics penning Deadpool and its successor, Agent X, for fifteen issues. She began her five-year run on Birds of Prey with issue #56, and continued until issue #108, with a rotating team of artists.
Soon after, she began an eight-issue run on Action Comics with John Byrne, where she introduced Livewire into comic continuity. She subsequently wrote a six-issue miniseries called Villains United that tied heavily into the Infinite Crisis, and its successor, the six-issue miniseries Secret Six.
With some ideas from Grant Morrison, Gail Simone co-created the new Atom character, Ryan Choi. After eighteen issues, she left the title and started writing Wonder Woman from issue fourteen. Gail Simone teamed up with Nicola Scott again to write a new Secret Six ongoing series.
In 2010, after encouragement from DC Comics Chief Creative Officer and fellow writer, Geoff Johns, Simone relaunched Birds of Prey with artist Ed Benes who she had worked with previously on the first volume. She left Wonder Woman after the special 600th anniversary issue. In 2011, Gail started DC's New 52 writing Batgirl and co-writing the Fury of Firestorm.
Outside of DC, Gail has worked on Dynamite's Red Sonja, Dark Horse’s Tomb Raider, Marvel’s Domino, and Domino: Hot Shots, Oni Press’s Catalyst Prime: Seven Days, and Wildstorm’s Gen 13.
Gail has also penned a few episodes of animated series, including Justice League Unlimited, Revisioned: Tomb Raider, Batman: The Brave and the Bold and My Little Pony: Friendship is Magic.
Her work has been nominated for a number of awards including the GLAAD Media Award, and she is the recipient of a 2017 San Diego Comic Con Inkpot Award.